Osmond J D'Cruz Selected Research

6- dihydro- 3'- azidothymidine- 5'- (p- bromophenyl) methoxyalaninyl phosphate 5-bromo-6-methoxy-5

4/2008	Evaluation of local tolerance of the antiretroviral spermicide (WHI-07)-loaded gel-microemulsion in the porcine female reproductive tract.
12/2007	Preclinical evaluation of a dual-acting microbicidal prodrug WHI-07 in combination with vanadocene dithiocarbamate in the female reproductive tract of rabbit, pig, and cat.
1/2005	Antileukemic activity and cellular metabolism of the aryl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07).
4/2004	Antiretroviral spermicide WHI-07 prevents vaginal and rectal transmission of feline immunodeficiency virus in domestic cats.
11/2003	Developmental toxicology studies of WHI-07, a novel nucleoside analogue-based dual-function microbicide, administered intravaginally to rabbits.

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Osmond J D'Cruz Research Topics

Disease

10	Acquired Immunodeficiency Syndrome (AIDS) 03/2012 - 12/2002
6	Infections 02/2008 - 01/2004
5	Inflammation (Inflammations) 04/2008 - 12/2003
3	Lymphoma (Lymphomas) 04/2013 - 01/2003
3	HIV Infections (HIV Infection) 02/2008 - 01/2004
3	Multiple Myeloma 01/2005 - 12/2002
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 03/2015 - 01/2003
2	Neoplasms (Cancer) 01/2003 - 12/2002
2	Breast Neoplasms (Breast Cancer) 01/2003 - 12/2002
2	Ovarian Neoplasms (Ovarian Cancer) 01/2003 - 12/2002
2	Testicular Neoplasms (Testicular Cancer) 01/2003 - 12/2002
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2018
1	Cytokine Release Syndrome 01/2018
1	Superinfection 02/2008
1	Edema (Dropsy) 12/2007
1	Colitis 08/2007
1	Cellulitis 08/2007
1	Endometriosis 08/2007
1	Peritonitis 08/2007
1	Sunburn 08/2007
1	Leukemia 01/2005
1	Feline Acquired Immunodeficiency Syndrome (FAIDS) 04/2004
1	Feminization 01/2004
1	Fetal Resorption 11/2003
1	Body Weight (Weight, Body) 11/2003
1	Wilms Tumor (Wilm's Tumor) 01/2003
1	Colonic Neoplasms (Colon Cancer) 01/2003
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2003
1	Hepatoblastoma 01/2003
1	Glioblastoma (Glioblastoma Multiforme) 12/2002

Drug/Important Bio-Agent (IBA)

6	Anti-Infective Agents (Microbicides)IBA 03/2012 - 12/2002
5	6- dihydro- 3'- azidothymidine- 5'- (p- bromophenyl) methoxyalaninyl phosphate 5-bromo-6-methoxy-5IBA 04/2008 - 11/2003
4	Pharmaceutical PreparationsIBA 03/2012 - 12/2004
3	Biomarkers (Surrogate Marker)IBA 01/2018 - 12/2007
3	Contraceptive Agents (Contraceptives)IBA 04/2008 - 01/2003
3	stampidineIBA 02/2008 - 12/2003
3	NucleosidesIBA 08/2006 - 01/2005
2	HI 443IBA 03/2012 - 12/2004
2	Local Anti-Infective Agents (Antiseptics)IBA 02/2008 - 07/2006
2	VanadiumIBA 12/2007 - 04/2004
1	Transforming Growth Factor beta (TGF-beta)IBA 01/2018
1	CytokinesIBA 01/2018
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2018
1	ChemokinesIBA 01/2018
1	Protein Kinase InhibitorsIBA 04/2013
1	ThioureaIBA 02/2008
1	NF-kappa B (NF-kB)IBA 12/2007
1	deoxyuridine triphosphateIBA 12/2007
1	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 12/2007
1	Fluorescein-5-isothiocyanate (FITC)IBA 12/2007
1	WHI P131IBA 08/2007
1	Janus Kinase 3IBA 08/2007
1	DNA (Deoxyribonucleic Acid)IBA 08/2006
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 08/2006
1	Human immunodeficiency virus 1 reverse transcriptaseIBA 07/2006
1	EnzymesIBA 03/2006
1	HI 236IBA 10/2005
1	Antiviral Agents (Antivirals)IBA 07/2005
1	Zidovudine (Retrovir)FDA LinkGeneric 01/2005
1	Nucleic AcidsIBA 01/2005
1	Phosphates (Orthophosphate)IBA 01/2005
1	Diphosphates (Pyrophosphates)IBA 01/2005
1	Interleukin-8 (Interleukin 8)IBA 01/2005
1	Interleukin-18 (Interleukin 18)IBA 01/2005
1	triphosphoric acid (triphosphate)IBA 01/2005
1	bis(cyclopentadienyl)- N,N- diethyldithiocarbamato triflate saltIBA 04/2004
1	Biological FactorsIBA 01/2004
1	5- Bromo- 6- methoxy- 5,6- dihydro- 3'- azidothymidine- 5'- (p- methoxyphenyl)methoxyalaninyl phosphateIBA 01/2003
1	benzenearsonic acidIBA 01/2003
1	SultanIBA 01/2003
1	pyrimidineIBA 01/2003
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 12/2002
1	Cisplatin (Platino)FDA LinkGeneric 12/2002
1	bis(4,7- dimethyl- 1,10- phenanthroline)sulfatooxovanadium(IV)IBA 12/2002

Therapy/Procedure

3	Therapeutics 07/2006 - 01/2003
2	Drug Therapy (Chemotherapy) 03/2015 - 08/2006
2	Intravaginal Administration 04/2008 - 12/2007
2	Lasers (Laser) 12/2007 - 01/2003
1	Highly Active Antiretroviral Therapy (HAART) 08/2006